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CHAPTER 14 - GASTROINTESTINAL TRACT
Histology Guide
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MICROGRAPH

NAME
EM 018 Gastric Gland
TISSUE
Stomach
(rat)
IMAGE SIZE
7,500 x 6,400 pixels
183 MB
FILE SIZES
31,975 KB (grayscale)
32,874 KB (color)
MAGNIFICATION
7,000x
PIXEL SIZE
3.455 nm
SOURCE
David G. Chase
Veteran's Administration Hospital
Sepulveda, CA

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EM 018 Gastric Gland

Enteroendocrine Cell

Transmission electron microscopy (TEM) of the base of a gastric gland.

Enteroendocrine cells are specialized secretory cells found in the simple columnar epithelium of the gastrointestinal tract. They release hormones from their basal surface that diffuse to nearby cells (paracrine) or into the bloodstream (endocrine).

are scattered among the cells in gastric glands.

  • (blue) / Nuclear Envelope (purple)
  • (black) - numerous, small dense granules contain hormones that vary depending on the type of enteroendocrine cell
    • Released from the basal surface
  • Golgi Apparatus (not visible)
  • (red)
  • (cyan) - many dispersed cisternae
  • (orange) - non-membrane bound structures involved in lipid metabolism
  • Cytoplasm (tan)

Courtesy of David G. Chase, Veteran's Administration Hospital, Sepulveda, CA.

Chief Cells

Chief cells can be identified by their large secretion granules near the apical surface. A is seen at the bottom of the section, while parts of at least four other chief cells are seen at the top of the section.

  • (blue)
  • (purple) - numerous, large granules in the apical region
  • (yellow) - well-developed in these secretory cells
  • (red)
  • (cyan) - abundant cisternae throughout the cytoplasm
  • Cytoplasm (dark green)

Parietal cells

Parietal cells can be identified by (1) canaliculi or the tubulovesicular system (e.g., tubules and cisternae) and (2) the large number of mitochondria. The presence of canaliculi or the tubulovesicular system indicates whether the cell is actively secreting hydrochloric acid (HCl) or are "resting" cells, respectively.

Parts of two "resting" parietal cells are seen on the and .

  • Nuclei - are not visible in this section
  • (white) - abundant tubules and cisternae that contain the endocytosized plasma membrane
  • (red) - large numbers to provide energy for acid production
  • Cytoplasm (light green)
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