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CHAPTER 14 - GASTROINTESTINAL TRACT
Histology Guide
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MICROGRAPH

NAME
EM 019 Small Intestine
TISSUE
Small Intestine
(rat)
IMAGE SIZE
8,834 x 11,338 pixels
382 MB
FILE SIZES
85,524 KB (grayscale)
86,798 KB (color)
MAGNIFICATION
Unknown
PIXEL SIZE
4.781 nm
SOURCE
Stanley L. Erlandsen
Department of Genetics, Cell Biology and Development
School of Medicine
University of Minnesota
Minneapolis, MN

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EM 019 Small Intestine

Small Intestine

Transmission electron micrograph (TEM) of the simple columnar epithelium with goblet cells that lines the small intestine.

  • Intestinal Absorptive cells (enterocytes; light green) - transport molecules across the epithelium
    • - increase the surface area of the apical membrane
    • (yellow) - well-developed in this secretory cell
    • (red) - abundant in the apical region to provide energy for transport of molecules
    • Endoplasmic Reticulum (cyan)
    • Cytoplasm (light green)
  • Goblet Cell (dark green) - secrete mucins that form mucus
    • (purple) - large, densely packed near the apical surface
    • (yellow) - well-developed in this secretory cell
    • Mitochondria (red)
    • (cyan) - flattened cisternae fill the cytoplasm
    • Cytoplasm (dark green)

The (dark purple) is the thin, fuzzy line that separates the epithelium from the underlying connective tissue.

The lymphocyte infiltration of this epithelium is discussed on the next page.

Immune Infiltration

Large numbers of immune cells are found in the gastrointestinal tract. This region of the intestinal epithelium was undergoing infiltration by lymphocytes.

Lymphocytes (,) are found between the absorptive and goblet cells.

can be seen extending pseudopods through gaps in the basal lamina.

Lymphocytes have relatively few organelles.

  • Nucleus (blue)
  • Golgi Apparatus (yellow)
  • Mitochondria (red)
  • Endoplasmic reticulum (cyan)
  • Cytoplasm (tan)

An excellent example of a is seen in lamina propria beneath the goblet cell.

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