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CHAPTER 14 - GASTROINTESTINAL TRACT
Histology Guide
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MICROGRAPH

NAME
EM 030 Parietal Cell
TISSUE
Stomach
(rat)
IMAGE SIZE
6,633 x 7,012 pixels
173 MB
FILE SIZES
28,093 KB (grayscale)
29,313 KB (color)
MAGNIFICATION
Unknown
PIXEL SIZE
2.170 nm
SOURCE
Susumu Ito
Department of Anatomy
Harvard Medical School
Boston, MA

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EM 030 Parietal Cell

Parietal Cell

Transmission electron microscopy (TEM) of the epithelium of a gastric gland.

Parietal cell structure changes depending on their functional status. When stimulated, tubulovesicles fuse with the apical surface, creating deep infoldings (canaliculi). As acid secretion decreases, the endocytosis of canaliculi reduces the surface area.

These parietal cells are not involved in acid production.

  • (green) - large, pear-shaped cells with an extensive network of intracellular canaliculi
    • Tubulovesicles (,; orange) - decrease the surface area by endocytosis of plasma membrane into vesicles and tubules
      • Store proton pumps when the cell is not actively secreting acid
      • Fuse with the apical surface when the cell is stimulated to produce acid
    • - contain numerous mitochondria to provide energy for acid production
  • (tan) - secrete digestive enzymes (pepsinogen and gastric lipases)
    • Golgi Apparatus (yellow) - well-developed in a juxtanuclear position
    • Secretion Granules (purple) - large granules fill the apical region of the cells

Subcellular Structures

  • Nucleus (blue) / Nucleolus (yellow) / Nuclear Envelope (purple)
  • Golgi Apparatus (yellow)
  • Mitochondria (red)
  • Endoplasmic Reticulum (cyan)
  • Lysosomes (black)

Courtesy of Susumu Ito, Department of Anatomy, Harvard Medical School, Boston, MA.

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