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CHAPTER 13 - ENDOCRINE GLANDS
Histology Guide
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MICROGRAPH

NAME
RD 219 Thyroid
TISSUE
Thyroid
IMAGE SIZE
10,227 x 7,567 pixels
221 MB
FILE SIZES
50,803 KB (grayscale)
51,774 (color)
MAGNIFICATION
Unknown
PIXEL SIZE
3.509 nm
SOURCE
Ronald W. Dudek
Brody School of Medicine
East Carolina University
Greenville, North Carolina

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RD 219 Thyroid

Follicular Cells

Transmission electron micrograph (TEM) of the wall of a follicle in the thyroid.

Follicles are the structural and functional units of a thyroid gland. They are spherical with a wall made up of cuboidal cells, the follicular cells. The central lumens act as storage compartments filled with colloid composed mostly of thyroglobulin.

During secretion, the follicular cells take up colloid into lysosomes that release thyroid hormones by degradation of the iodinated thyroglobulin.

  • (green) – simple cuboidal epithelium whose lumenal surface is covered with projections into the colloid
    • Nuceli (blue) / Nuclear Envelope (purple)
    • (yellow) – well-developed in these secretory cells
    • (RER, cyan) – large amounts for the production of thyroglobulin
      • Distended cisterna of newly synthesized protein
    • (black) – release thyroid hormones from endocytosed colloid
      • Larger in diameter than in most cells
  • (yellow) - central lumen filled with iodinated thyroglobulin
  • (tan) - partially collapsed

Courtesy of Ronald W. Dudek, Brody School of Medicine, East Carolina University, Greenville, North Carolina.

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