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CHAPTER 2 - EPITHELIUM
Histology Guide
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FIGURE

NAME
Fig 015 Intercellular Junctions
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T. Clark Brelje
University of Minnesota
Minneapolis, MN
Modified from Public Domain

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University of Minnesota
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Robert L. Sorenson, Ph.D.

University of Minnesota
Department of Genetics, Cell Biology and Development
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Minneapolis, MN 55455

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Fig 015 Intercellular Junctions

Intercellular Junctions

Lateral specializations between epithelial cells near the apical surface of the epithelium.

  • Tight Junctions (zonula occludens) - closely associated plasma membranes joined together by transmembrane protein complexes
    • Forms a barrier that prevents molecules from passing between cells
  • Zonula Adherens (adherent junctions) - ribbon-like structures of cadherins that encircle a cell
    • Intracellulary bound to actin filaments by catenins
    • Regulates tension and shape of the apical region of the cell
    • Primary force that keeps cells together
  • Desmosomes (macula adherens) - patch-like structures specialized for cell-to-cell adhesion
    • Intracellulary bound to intermediate filaments (e.g., keratins) through placques of desmoplakins (similar to catenins)
    • Incredibly strong spot weld-like adhesions

Zonula occludens and zonula adherens together are known as the junctional complex by electron microscopy and terminal bar by light microscopy.

© 2005-2026. T. Clark Brelje and Robert L. Sorenson